Endocrine Abstracts

Giant-cell tumor is a skeletal disorder that occurs secondarily to hyperparathyroidism and is caused by long-term stimulation of parathyroid hormone (PTH) excess. The overactivity and proliferation of osteoclasts stimulated by PTH breaks down bone and leads to replacement of bone matrix and thinning of the cortex. True giant-cell tumor is a rare jaw osteolytic benign tumor belonging to the larger family of giant-cell tumors.We report the case of a 47 yea...

Background: Gigantism indicates excessive secretion of growth hormone (GH) during childhood Pituitary gigantism is very rare and the description of the disease is limited to small series and case reports. Here, we report a case of pituitary gigantism in a child revealed with visual defect.Case report: A 14-year-old boy presented with headache and left visual loss. On examination, he had visual acuity in his right eye of 2/10. His height was 178.0 cm (3 c...

Background: Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudo-hypertrophy. Here, we report a case of Hoffman syndrome aggravated by statin therapy.Case report: We describe the case of a 60 year old woman with primary hypothyroidism who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelling of th...

Introduction: Therapeutic education of diabetic patients is an integral part of management care of the disease and a permanent way to empower patients and to promote their self-care. The purpose of this study is to evaluate the knowledge of diabetic patients about their disease.Patients and methods: This prospective study has been conducted during 9 months and included 312 patients with type 2 diabetes mellitus (T2DM) diagnosed at least 3 months ago. All...

Introduction: Among pituitary adenomas comprise approximately 10% of benign pituitary adenomas. These adenomas often arise in middle-aged men presenting with tumoral syndrome and endocrine profile of primary hypogonadism. Gonadotroph adenomas are more difficult to diagnose in women generally in perimenopausal or postmenopausal periods.Case report: A 33-year-old woman with a 10 years of history of sterility with dysmenorrhea and pelvic pain in relation to...

Background: The IL-10 promoter polymorphisms −1082G/A, −819C/T, and −592C/A have been consistently associated with type 2 diabetes (T2DM). We examined whether these polymorphisms variants are also associated with progression of diabetic nephropathy (DN).Methods: These promoter variants were genotyped in 917 T2DM patients comprising 515 DN patients and 402 control patients without nephropathy (DWN), together with 748 non-diabetic control...

Introduction: Differentiation between mild Cushing’s syndrome (CS) and Pseudo-Cushing syndrome (PCS) can be extremely difficult. A Pseudo-Cushing state can be defined as a part or all of the clinical features that resemble a true CS with some evidence of hypercotisolism but the resolution of the underlying primitive state results in the disappearance of this Cushing state-like. The aim of this work was to describe the diagnostic difficulties of 24 cases of PCS.<p clas...

Introduction: The management of diabetes goes through the education but also the management of acute and chronic complications. Among the complications, erectile dysfunction are too often forgotten as they actually affect the quality of life. The repercussions of this complication incite the clinician to look for it among the other complications of diabetes. The aim of our study is to evaluate the prevalence of erectile dysfunction in a diabetic population and to evaluate its ...

Introduction: Premature ovarian failure (POF) is defined as amenorrhea lasting more than four months before the age of 40 with a high level of gonadotropins in at least two separate samples. The aim of this work was to describe the etiological profile of a series of Tunisian women followed for POF.Patients and methods: It is a descriptive study of 42 cases of POF collected in the endocrinology department of Sousse between 2000 and 2017.<p class="abst...

Introduction: The therapeutic management of premature ovarian failure (POF) consists of a hormone replacement therapy that must be regular to avoid cardiovascular and bone complications as well as psychological management. The objective of this work was to study complications at 15 years of evolution of 42 tunisian women followed for POF.Patients and methods: It’s a retrospective study of 42 patients followed in the endocrinology department of Souss...